世界*實驗材料供應商 Integralmolecular 正式授權上海起發為其中國代理， Integralmolecular 在一直是行業的*,一直為廣大科研客戶提供zui為優質的產品和服務,上海起發一直秉承為中國科研客戶帶來的產品，的服務，簽約 Integralmolecular 就是為了給廣大科研客戶帶來更加*的產品和服務,您的滿意將是我們zui大的收獲

 Integralmolecular 中國代理, Integralmolecular 上海代理， Integralmolecular 北京代理，Integralmolecular 廣東代理， Integralmolecular 江蘇代理Integralmolecular 湖北代理,Integralmolecular 天津,Integralmolecular 黑龍江代理,Integralmolecular 內蒙古代理,Integralmolecular 吉林代理,Integralmolecular 福建代理, Integralmolecular 江蘇代理, Integralmolecular 浙江代理, Integralmolecular 四川代理,

LIPOPARTICLE TECHNOLOGY

Application Notes

THE LIPOPARTICLE
Lipoparticles incorporate high concentrations of properly folded and oriented membrane proteins on their surface. GPCRs, ion channels, and other complex membrane proteins can be incorporated into Lipoparticles at concentrations of 50-200 pmol/mg, 10-100 fold greater than cells or membrane preparations. Because Lipoparticles are virus-like particles （VLPs） based on the natural retroviral budding process, they are uniform in diameter （~150 nm） and maintain the orientation of incorporated membrane proteins. Integral Molecular produces, purifies, and delivers custom Lipoparticles containing user specified membrane proteins for applications in antibody development and drug discovery.

MODIFIED LIPOPARTICLES
Integral Molecular offers biochemically modified Lipoparticles containing biotin tags and fluorophores to enable membrane proteins to be captured onto solid supports and visualized without disrupting the conformation of incorporated receptor targets. Modified Lipoparticles are suited for use in specialized antibody development applications including:

ADVANTAGES
Lipoparticles offer distinct advantages over traditional sources of membrane proteins such as whole cells or membrane preparations:

Incorporation of difficult membrane proteins 
Lipoparticles can incorporate oligomeric and multispanning membrane proteins in their correct topology. Receptors that are toxic or poorly trafficked can also be incorporated into Lipoparticles. 

High purity and high concentrations of membrane proteins
Lipoparticles provide a source of concentrated membrane proteins that are free of cytoplasmic proteins and misoriented proteins, improving assay sensitivity and the specificity of immune responses. 

Convenient and consistent source of membrane proteins
Lipoparticles maintain membrane proteins in their native lipid environment, preserving protein conformation. Lipoparticles are shipped ready to use and are stable for months with refrigeration, thereby eliminating end-user preparation steps and reducing experimental variability. 
 

LIPOPARTICLE STRUCTURE
The Lipoparticle structure is based on membrane-enveloped retroviruses. Non-infectious, retroviral virus-like particles （VLPs） are produced when the viral protein 'Gag' buds through the host cell membrane. The Gag protein forms a core which becomes enwrapped by the cell membrane. Once the membrane ‘pinches’ off, newly formed Lipoparticles diffuse away from the cell, carrying target membrane proteins with it. Since the lipid membrane surrounding the Lipoparticle is derived directly from the host cell membrane, the incorporated receptors remain correctly oriented in a native lipid environment. Lipoparticles contain no viral genome or Envelope protein, and are replication incompetent and non-infectious, rendering them safe to manipulate in a standard laboratory environment.

LIPOPARTICLE QUALITY CONTROL
At Integral Molecular, Lipoparticles undergo rigorous quality control before they are shipped. As a result, the Lipoparticles you receive are highly purified, homogeneous, and stable for nths to years. Maintaining

• Immunization
• Phage and yeast display
• Screening for and characterizing MAbs
• Ligand binding assays
• Probing cells and microarrays
• Biosensor binding kinetics

Application versatility
Lipoparticles can be used with conventional formats such as microplates and beads, but their small size, exceptional purity, and stability also make them amenable to formats that are otherwise difficult for membrane proteins, such as microfluidics, microarrays, and biosensors. 
 

我們公司zui大優勢是*的采購，

1：基本什么都能進口，血清，抗體，耗材，還有部分限制進口的，

2：貨品全，現經營過700多個品牌，基本所有生物試劑耗材都可以進口，特別是冷偏的產品那就更有優勢，

3：提供加急服務，一般1-2周到貨，超過時限加急費全免

4：價格公道，絕大部分價格有優勢，當然不能保證100%產品都是,因為意味著沒有服務.

5：良好的信譽，大部分客戶我們提供貨到付款服務，客戶包括清華，北大 交大 復旦，中山等100多所大學，ROCHE，阿斯利康，國藥 ，fisher等500多家公司

6：我們還是Santa,Advanced Biotechnologies Inc, Integralmolecular,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, GePromegaridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,Integralmolecular, Polysciences,prospecbi, QA-BIO,quickzyme,FULLERLABS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等幾十家國外公司授權代理。
7：我們還是invitrogen,qiagen,Integralmolecularam,sigma;Promega,roche,merck, rnd,BD, GE,pierce,BioLegend等*批發，歡迎合作。

上海起發實驗試劑有限公司
：楊建輝
400：
辦公：
*8006

企業:
:http://www.qfbio.com/
地址：上海市浦東新區晨陽路225弄東方現代商業廣場46號303室(近東亭路)