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克隆號(hào)為H09的IDH1（isocitrate dehydrogenase 1, 異檸檬酸鹽脫氫酶1）鼠單克隆抗體為Dianova公司近期推出的產(chǎn)品之一，此抗體可特異性的檢測(cè)腦組織腫瘤中IDH1基因的R132H點(diǎn)突變。IDH1基因的第132密碼子的雜合突變是II 和III級(jí)神經(jīng)膠質(zhì)瘤（根據(jù)WHO的腫瘤學(xué)分類(lèi)）的頻發(fā)事件。在大約70％的星形膠質(zhì)細(xì)胞瘤和少突神經(jīng)膠質(zhì)細(xì)胞瘤可發(fā)現(xiàn)IDH1基因的R132H點(diǎn)突變。

IDH1基因R132H突變?cè)诓糠帜X腫瘤中的頻發(fā)現(xiàn)象使克隆號(hào)為H09的IDH1抗體可高靈敏性和高特異性的用于此類(lèi)腫瘤的鑒別診斷中：如從原發(fā)性膠質(zhì)母細(xì)胞瘤中區(qū)分出間變性星形細(xì)胞瘤、從毛細(xì)胞型星形細(xì)胞瘤或室管膜（細(xì)胞）瘤中區(qū)分出彌漫性星形細(xì)胞瘤（WHO分類(lèi)II級(jí)），也可以用于具有IDH1突變的腫瘤細(xì)胞浸潤(rùn)前沿的與反應(yīng)性神經(jīng)膠質(zhì)增多癥的區(qū)分。因此，由于其高靈敏性和高特異性，此抗體在腦部腫瘤的分類(lèi)分級(jí)中以及在檢測(cè)單一或少量浸潤(rùn)腫瘤細(xì)胞時(shí)是非常有用的。

DIA-310 – Anti-CD31 (Ms) aus Ratte (Klon: SZ31) für Paraffingewebe aus Maus – 500 µl

Art.-Nr.                           DIA-310

Spezifität                         CD31 (PECAM-1)

Spezies-Reaktivität                Schwein

                                   Maus

Wirtsspezies                       Ratte

Isotyp                             IgG2a

Klon                                SZ31

Klonalität (Mono-/Polyklonal)       monoklonal

Anwendung                           Immunhistochemie (IHC)

                                    Immunhistochemie (Paraffingewebe)
                                    Gefrierschnitte (IHC-F)
                                    Western Blot

Konjugation                          unkonjugiert

Format                               Lyophilisat

                                     gereinigter Antikörper (aus Kulturüberstand)

Produktlinie / Thema                  Angiogenese

                                      CD-Marker
                                      Immunhistochemie

Zweckbestimmung                        nur für Forschungszwecke

Suchcode                               DIA310

Hersler / Marke                     dianova

DIA-310 – Anti-CD31 (Ms) aus Ratte (Klon: SZ31) für Paraffingewebe aus Maus – 500 µl

Art.-Nr.

DIA-310

Spezifität

CD31 (PECAM-1)

Spezies-Reaktivität

Schwein
Maus

Wirtsspezies

Ratte

Isotyp

IgG2a

Klon

SZ31

Klonalität (Mono-/Polyklonal)

monoklonal

Anwendung

Immunhistochemie (IHC)
Immunhistochemie (Paraffingewebe)
Gefrierschnitte (IHC-F)
Western Blot

Konjugation

unkonjugiert

Format

Lyophilisat
gereinigter Antikörper (aus Kulturüberstand)

Produktlinie / Thema

Angiogenese
CD-Marker
Immunhistochemie

Zweckbestimmung

nur für Forschungszwecke

Suchcode

DIA310

Hersler / Marke

dianova

Reactivity

Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.
CD31, also known as PECAM-1 (Plaet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, plaets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells.CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.

Immunohistochemistry of mouse CD31 (PECAM-1) in formalin-fixed paraffin-embedded tissue sections

The monoclonal antibody clone SZ31 reacts specifically with endothelial cells in vessels and capillaries of:

aorta

aortic origin

endocardium

small intestine

small intestine

colon

brain

lymph nodes

bone marrow

mesenterial vessels

kidney

pancreas

(pictures courtesy of Prof. Dr. Robert Klopfleisch, Institute of Pathology, Department of Veterinary Pathology, Berlin, Germany)

Lung

Muscle

Spinal

Liver

Adenocarcinoma

Adenocarcinoma

(pictures courtesy of Prof.Dr.H.Stein, Institute of Pathology, Charité Campus Benjamin Franklin, Berlin, Germany)

Western blot analysis

Immunoblot of extracts from murine lung, J558L cells and m-Lend cells using CD31 rat monoclonal antibody clone SZ31 (DIA-310 1:5.000) and goat anti-rat-HRP antibody (1:10.000).

Lane:

1. J558 cells (CD31-), 25μg lysate
2. murine lung, 25μg lysate
3. blank
4. m-Lend cells (CD31+), 12.5μg lysate

References

1. Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A.
   Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
   J.Biol.Chem. 286: 11185-11194, 2011
2. Kröger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM. Placental vasculogenesis is
   regulated by keratin-mediated hyperoxia in murine decidual tissues. Am.J.Pathol. 178(4): 1587-1590, 2011
3. Jiang J, Thyagarajan-Sahu A, Krchnák V, Jedinak A, Sandusky GE, et al. NAHA, a Novel Hydroxamic Acid-Derivative,
   Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. PLoS ONE 7(3): e34283, 2012
4. Copeland BT, Bowman MJ, Ashman LK. Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic
   Spread of Prostate Cancer in the TRAMP Model. Mol Cancer Res. 11(1):95-105, 2013
5. Agliano A, Martin-Padura I, Marighetti P, Gregato G, Calleri A, Prior C, Redrado M, Calvo A, Bertolini F. Therapeutic effect
   of lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendritic
   cell neoplasm. Clin Cancer Res. 1;17(19):6163-73, 2011
6. Ferretti E, Montagna D, Di Carlo E, Cocco C, Ribatti D, Ognio E, Sorrentino C, Lisini D, Bertaina A, Locali F, Pistoia V,
   Airoldi I. Absence of IL-12Rβ2 in CD33(+)CD38(+) pediatric acute myeloid leukemia cells favours progression in
   NOD/SCID/IL2RϒC-deficient mice. Leukemia 26(2):225-35,2012

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